Historic Doniphan, MO was settled in 1819 near an Indian village and French trading post. Its historic district is centered around the Ripley County Courthouse and other buildings, all on the National Register of Historic Places. It is on the first federal highway west of the Mississippi River, and on the famous Cherokee Trail of Tears. Civil War sites are in every corner of the county. A downtown historical museum and gift shop displays many artifacts and crafts.

The City of Doniphan is located near the center of Ripley County on the East bank of the Current River. Ripley County is located in the Ozark Foothills region of Missouri near the Arkansas border. The County is bordered by Butler County to the East, Carter County to the North and Oregon County to the West. To the South are the Arkansas counties of Randolph and Clay. Doniphan lies approximately 30 miles West of Poplar Bluff, Missouri, 10 miles North of the Arkansas border, 180 miles East of Springfield, Missouri, and 180 miles South of St. Louis, Missouri. U.S. Highway 160 runs East/West thru Doniphan, as do two State Highways, 21 and 142.

Ripley County is not only a great place to visit but a great place to live. It offers all of the small town benefits, but is unique in the amount of services it has to offer its residents. A quality public education system, quality health care, libraries, museums, parks, recreational opportunities, public airport, effective law enforcement and local government, many community clubs, organizations and events.